Light-Controlled Generation of Singlet Oxygen within a Discrete Dual-Stage Metallacycle for Cancer Therapy. Yi Qin, Li-Jun Chen, Fangyuan Dong, Shu-Ting Jiang, Guang-Qiang Yin, Xiaopeng Li, Yang Tian, Hai-Bo Yang.Lighting the Flavin Decorated Ruthenium(II) Polyimine Complexes: A Theoretical Investigation. Huimin Guo, Can Dang, Jianzhang Zhao, Bernhard Dick.Autoinhibitory Feedback Control over Photodynamic Action. Nur Zafer Yurt, Yusuf Cakmak, Gülsüm Tekin, Serdar Karakurt, Sundus Erbas-Cakmak. The Journal of Physical Chemistry C 2019, 123 Exploring the Photophysics of Polyfluorinated Phthalocyanine Derivatives as Potential Theranostic Agents. Basak Koca, Esin Hamuryudan, Saron Catak, Ali Erdogmus, Antonio Monari, Viktorya Aviyente.Smart Aza-BODIPY Photosensitizer for Tumor Microenvironment-Enhanced Cancer Phototherapy. Yunyun Tang, Lei Xue, Qing Yu, Dapeng Chen, Zijin Cheng, Wenjun Wang, Jinjun Shao, Xiaochen Dong.pH-Activatable Singlet Oxygen-Generating Boron-dipyrromethenes (BODIPYs) for Photodynamic Therapy and Bioimaging. Sebastian Radunz, Stefanie Wedepohl, Mathilde Röhr, Marcelo Calderón, Harald Rune Tschiche, Ute Resch-Genger.Highly Efficient Singlet Oxygen Generation and High Oxidation Resistance Enhanced by Arsole-Polymer-Based Photosensitizer: Application as a Recyclable Photooxidation Catalyst. Susumu Tanaka, Toshiaki Enoki, Hiroaki Imoto, Yousuke Ooyama, Joji Ohshita, Takuji Kato, Kensuke Naka.The Journal of Physical Chemistry C 2020, 124 Conductance Behavior of Tetraphenyl-Aza-BODIPYs. Fabrics Attached with Highly Efficient Aggregation-Induced Emission Photosensitizer: Toward Self-Antiviral Personal Protective Equipment. Lee, Wei Wang, Qingqin Tan, Zhaoyan Zhao, Ben Zhong Tang, Xi Huang. Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy. Thanh Chung Pham, Van-Nghia Nguyen, Yeonghwan Choi, Songyi Lee, Juyoung Yoon.Discovery of Meso-(meta-Pyridinium) BODIPY Photosensitizers: In Vitro and In Vivo Evaluations for Antimicrobial Photodynamic Therapy. Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li, Xiaochun Dong, Weili Zhao.Selectively Lighting Up Singlet Oxygen via Aggregation-Induced Electrochemiluminescence Energy Transfer. Xuwen Gao, Huimin Zhao, Dongyang Wang, Yuqi Xu, Bin Zhang, Guizheng Zou.Synthesis of Aza-BODIPYs, Their Differential Binding for Cu(II), and Results of Bioimaging as Fluorescent Dyes of Langerhans β-Cells. Espinoza, Héctor Frayde-Gómez, Ignacio A. Aguilera, Víctor García-González, Manuel Alatorre-Meda, Eustolia Rodríguez-Velázquez, Karla A. This article is cited by 303 publications. In vitro efficacy demonstrated that the SPTA derivatives can be activated within cells and one analogue is measured to have an EC 50 value of 5.8 nM when assayed in the MRC5 cell line. For example, systems have been constructed such that the excited state energy of the photosensitizer can be decayed by a rapid photoinduced electron transfer (PET) mechanism, resulting in virtually no singlet oxygen being generated, but when the amine receptor is protonated the PET mechanism does not operate and singlet oxygen is produced. A series of SPTA analogues with pH responsive receptors of varying p K a are presented, in which the generation of singlet oxygen is shown to be dependent upon a proton source. A new approach to achieving selectivity for photodynamic therapy based upon the reversible off/on switching of the key therapeutic property (singlet oxygen generation) of a supramolecular photonic therapeutic agent (SPTA) in response to an external stimulus in the surrounding microenvironment is described.
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